Some programs that run on the IBM PC XT can be run on the HP 95LX. The program must be able to work with an MDA display (no graphics). The program must be able to execute within the available system RAM. A program that uses the serial port may not work, depending on the specifics of how it accesses the serial port. You may need a RAM card for more file storage.
If the program meets these criteria, it is worth a try. Back up your files before you experiment.
Note that all programs that run on the HP 95LX may not be easy to use. The screen (16 lines by 40 columns) may require extra scrolling. (The display is moved around the 25 line by 80 column screen memory by pressing (ALT) and an arrow key at the same time).